Sequential heart and autologous stem cell transplantation for light-chain cardiac amyloidosis
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چکیده
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منابع مشابه
Cardiac amyloidosis
Amyloidosis is a family of disorders of the immune system in which one or more organs in the body accumulate amyloid. There are four different forms of amyloidosis: systemic amyloid light chain (AL) amyloidosis, amyloid A (AA) amyloidosis, hereditary, and senile amyloidosis. The abnormal proteins can be found as Bence-Jones proteins in urine mainly in patients with light chain (AL) amyloidosis....
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munoglobulin light-chain (AL) amyloidosis with heart involvement. QJM 1998;91:141-57. 6. Skinner M, Sanchorawala V, Seldin DC, et al. High-dose melphalan and autologous stem-cell transplantation in patients with AL amyloidosis: an 8-year study. Ann Intern Med 2004;140:85-93. 7. Falk RH, Comenzo RL, Skinner M. The systemic amyloidoses. N Engl J Med 1997;337:898-909. 8. Kyle RA, Greipp PR. Amyloi...
متن کاملLongitudinal Strain Imaging in Light-Chain Cardiac Amyloidosis
The systemic amyloidoses are a group of uncommon diseases characterized by extracellular accumulation of fibrillar proteins, leading to loss of normal tissue architecture and function (1). Light-chain (AL) amyloidosis, which is probably the most frequent form, can potentially involve any organ, but when the heart is affected, the outcome is particularly poor, with a median survival of 4 to 6 mo...
متن کاملCardiac transplantation followed by dose-intensive melphalan and autologous stem-cell transplantation for light chain amyloidosis and heart failure.
BACKGROUND Patients with light chain (AL) amyloidosis who present with severe heart failure due to cardiac involvement rarely survive more than 6 months. Survival after cardiac transplantation is markedly reduced due to the progression of amyloidosis. Autologous stem-cell transplantation (ASCT) has become a common therapy for AL amyloidosis, but there is an exceedingly high treatment-related mo...
متن کاملSuccessful long-term outcome of the first combined heart and kidney transplant in a patient with systemic Al amyloidosis
Simultaneous cardiac and renal involvement is associated with a particularly poor prognosis in patients with AL amyloidosis (AL-A). We report the first case of a successful long-term outcome of combined heart and kidney transplantation not followed by autologous stem cell transplantation in a patient with systemic AL-A. The recipient was a 46-year-old man with end-stage renal failure associated...
متن کاملLongitudinal strain imaging in light-chain cardiac amyloidosis: can it help to refine the approach to treatment?
The systemic amyloidoses are a group of uncommon diseases characterized by extracellular accumulation of fibrillar proteins, leading to loss of normal tissue architecture and function (1). Light-chain (AL) amyloidosis, which is probably the most frequent form, can potentially involve any organ, but when the heart is affected, the outcome is particularly poor, with a median survival of 4 to 6 mo...
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